Boston: New Study Led by researchers at Beth Israel Deaconess Medical Center (BIDMC), it sheds light on genetic risk factors that can make individuals more susceptible to Covid-19.
Thousands of people test positive for the virus every day, and it is still in the shadow of doubt as people experience mild to no symptoms and others become seriously ill. According to the new Study Published in the New England Journal of Medicine (NEJM), Robert E. Schneider, head of the cardiovascular inefficiency division at BIDMC. Research led by Gerzten radiates an important process of covid-19, which opens new possibilities for the treatment of this disease.
Gersten, a professor of medicine at Harvard Medical School, shares that different patients affected by COVID-19 exhibit different symptoms and different degrees of severity, “Pre-existing conditions, especially heart and metabolic diseases, are risk factors for disease severity and outcomes, some of which are underlying causes of life-threatening disease The rest is not properly understood. ”
The findings published in NEJM explain the linkage of COVID-19 results to differences in the two regions of the human genome based on genetic evidence from patients in China, Europe and the United States. However, in order to differentiate from disease, scientists need to understand the role of proteins in the genome carrying the disease.
A database created by Gersten and colleagues of all proteins and metabolites for different regions of the human genome found that a genomic “hot spot” was associated with COVID-19 disease severity. This is a step forward for researchers to realize that the same region is related to protein, which has recently been implicated in the SARS-CoV-2 virus process that infects human cells.
“We have determined that the most expressed protein in the region is a co-receptor for the virus that causes COVID-19. Currently available antibody cocktails target the virus’s spike proteins. In turn, the work identifies which proteins our SARS-CoV-2 and other viruses bind to in the human body.” Said Gersten.
According to the report, the second area is related to a poorly understood protein, which plays a role in attracting immune cells called lymphocytes to sites of infection. The Study It also suggests that these genetic mutations and proteins may vary across races. Overall, these findings are important contributions to science for understanding the mysteries of COVID-19.


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