London: Johnson & Johnson launched a new large-scale late-stage trial on Monday to test the two-dose regimen of its experimental Covid-19 vaccine and the increasing benefits of a period of protection with a second dose.
US drug makers plan to enroll 30,000 participants for the study and run a one-dose trial with 60,000 volunteers beginning in September.
The UK arm of the study aims to recruit 6,000 participants and the rest of the Covid-19 cases in the United States, Belgium, Colombia, France, Germany, the Philippines, South Africa and Spain, it said.
Sal Foust, professor of pediatric immunology and epidemiology, said they were given the first dose of a placebo or experimental shot, currently called Ad26COV2, followed by a second dose or 57 days after the placebo. At University Hospital Southampton.
The trial follows the positive interim results of the company’s ongoing early-stage clinical study, which prompted a dose-dependent immune response of its vaccine candidate and is generally well tolerated.
“The study assesses the efficacy of the investigational vaccine after the first and second dose to evaluate the protection against the virus and the increasing benefits of the period of protection with the second dose,” J&J said in a statement.
Rival drug makers Pfizer and Biotech said last week that a 90-point efficacy of more than 90% of their potential Covid-19 shot intermediate data showed that vaccines against infectious disease could soon be ready for use.
While the Pfizer-Biotech Vaccine uses a new technology called messenger RNA, J&J uses cold virus and transmits genetic material from the coronavirus to the body to induce an immune response.
The platform, called AdWalk, is also used in the Ebola vaccine approved earlier this year.
“It is really important that we continue to experiment with different vaccines from many different manufacturers and be able to ensure supply to the UK and the global population,” Faust told reporters.
The study appointment will be completed in March 2021 and the trial will last for 12 months.


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